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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2C
All Species:
13.33
Human Site:
S23
Identified Species:
24.44
UniProt:
P25092
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25092
NP_004954.2
1073
123369
S23
Q
P
G
W
L
S
F
S
S
Q
V
S
Q
N
C
Chimpanzee
Pan troglodytes
XP_528746
1073
123536
T23
Q
P
G
W
L
S
L
T
S
K
V
S
Q
N
C
Rhesus Macaque
Macaca mulatta
XP_001089601
1073
123492
T23
Q
P
E
W
L
Y
L
T
S
Q
V
S
Q
N
C
Dog
Lupus familis
XP_543798
1072
122882
S32
S
Q
N
C
N
N
G
S
Y
E
I
S
V
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q3UWA6
1072
123214
A23
P
A
L
M
V
F
W
A
S
Q
V
R
Q
N
C
Rat
Rattus norvegicus
P23897
1072
123448
T33
R
Q
K
C
H
N
G
T
Y
E
I
S
V
L
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520217
1075
122497
A23
G
F
Q
V
L
G
W
A
T
T
G
N
P
H
C
Chicken
Gallus gallus
XP_416207
1070
123254
V23
S
L
Q
L
L
Q
Q
V
G
S
S
R
C
N
N
Frog
Xenopus laevis
NP_001079334
1065
122503
S28
E
A
N
C
M
S
G
S
L
T
M
N
V
I
M
Zebra Danio
Brachydanio rerio
XP_700803
484
55110
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
N72
A
I
E
D
V
N
K
N
P
N
L
L
P
G
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
T25
V
Q
N
L
P
D
T
T
V
A
P
R
T
K
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
N26
V
I
A
R
L
D
F
N
P
T
I
I
N
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.5
87.7
N.A.
81.8
82.4
N.A.
73.5
67.7
62.4
31.4
N.A.
27.9
N.A.
24.8
28.6
Protein Similarity:
100
99.5
98.7
93.5
N.A.
90.1
90.7
N.A.
83.7
80.6
77
37.3
N.A.
45.2
N.A.
45.2
46.3
P-Site Identity:
100
80
73.3
13.3
N.A.
40
6.6
N.A.
13.3
13.3
13.3
0
N.A.
0
N.A.
0
13.3
P-Site Similarity:
100
93.3
80
33.3
N.A.
60
40
N.A.
46.6
13.3
40
0
N.A.
26.6
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
8
0
0
0
0
16
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
24
0
0
0
0
0
0
0
0
8
0
39
% C
% Asp:
0
0
0
8
0
16
0
0
0
0
0
0
0
0
8
% D
% Glu:
8
0
16
0
0
0
0
0
0
16
0
0
0
8
0
% E
% Phe:
0
8
0
0
0
8
16
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
16
0
0
8
24
0
8
0
8
0
0
8
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
16
0
0
0
0
0
0
0
0
24
8
0
8
0
% I
% Lys:
0
0
8
0
0
0
8
0
0
8
0
0
0
8
8
% K
% Leu:
0
8
8
16
47
0
16
0
8
0
8
8
0
16
0
% L
% Met:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
24
% M
% Asn:
0
0
24
0
8
24
0
16
0
8
0
16
8
39
8
% N
% Pro:
8
24
0
0
8
0
0
0
16
0
8
0
16
0
0
% P
% Gln:
24
24
16
0
0
8
8
0
0
24
0
0
31
0
0
% Q
% Arg:
8
0
0
8
0
0
0
0
0
0
0
24
0
0
8
% R
% Ser:
16
0
0
0
0
24
0
24
31
8
8
39
0
0
0
% S
% Thr:
0
0
0
0
0
0
8
31
8
24
0
0
8
0
0
% T
% Val:
16
0
0
8
16
0
0
8
8
0
31
0
24
0
0
% V
% Trp:
0
0
0
24
0
0
16
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
16
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _